The Best Weight Loss Medications (GLP-1s)

Our Top Picks of 2025

We’ve reviewed and compared the most effective and popular GLP-1 medications on the market so that you don’t have to. Learn more about what’s available and what is right for you!

The content on this site, including any product recommendations related to medical weight loss, is for informational purposes only and does not constitute medical advice. Always consult with your healthcare provider before starting any new medication or treatment.

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Exploring GLP-1 Medications for Weight Management: A Balanced Overview

Just as finding the right support system can make a big difference in your wellness journey, understanding the options for weight management is key. GLP-1 receptor agonists are an innovative class of medications that work with your body’s natural systems to help manage weight. Let’s explore what they are and how they might fit into your health plan.

What Are GLP-1s? Understanding the Basics

GLP-1 stands for glucagon-like peptide-1. It’s a hormone your body naturally produces that helps regulate blood sugar and appetite. GLP-1 medications are designed to mimic the actions of this hormone, essentially amplifying its helpful effects.

Different Types and How They Work:

There are several GLP-1 medications available, each with a specific active ingredient. Some key examples include:

Semaglutide (found in Ozempic® and Wegovy®): This active ingredient is effective in managing blood sugar (Ozempic’s® primary use) and also promotes significant weight loss (the main purpose of Wegovy®).
Liraglutide (the active ingredient in Saxenda®): Specifically approved for weight management.
Tirzepatide (in Mounjaro® and Zepbound®): This medication acts like both GLP-1 and another similar hormone, leading to notable improvements in blood sugar and weight.
Other GLP-1s: Primarily used for type 2 diabetes management.

While some GLP-1s were initially developed for diabetes, their impact on weight has led to the development of medications like Wegovy and Saxenda specifically for weight management. It’s important to recognize that while they share a core mechanism, their approved uses and dosages can vary.

How GLP-1s Aid in Weight Loss: A Closer Look

GLP-1 medications support weight loss through several natural-feeling processes:

Slower Stomach Emptying: They help food digest more slowly, leading to a longer feeling of fullness after meals. Think of it as extending the “satisfied” feeling you get after eating.
Increased Satiety Signals: They communicate with your brain to reduce hunger and increase feelings of fullness. This can make it easier to manage portion sizes and reduce cravings.
Blood Sugar Regulation: They help your body release insulin when blood sugar is high and reduce the release of a hormone that raises it. This contributes to better metabolic health.

Effectiveness Compared to Other Options:

Clinical studies have shown that GLP-1 medications can be a very effective tool for weight loss when combined with lifestyle changes. Many individuals experience significant weight reduction. It’s important to have realistic expectations and understand that these medications work best as part of a comprehensive approach.

When comparing GLP-1s to over-the-counter “fat loss pills,” it’s crucial to understand the difference. GLP-1s are prescription medications that target hormonal pathways involved in appetite and metabolism. Many over-the-counter options lack strong scientific backing and may not have the same level of effectiveness or safety. GLP-1s are prescribed and monitored by healthcare professionals.

Choosing the Right GLP-1 for Your Needs

Selecting a GLP-1 medication, if it’s deemed appropriate for you, is a collaborative decision with your healthcare provider. They will consider several factors:

Your Medical Background: Existing health conditions, particularly diabetes, will influence the choice.
Your Weight Management Goals: The amount of weight you aim to lose and your overall health objectives will be discussed.
Potential Side Effects: Like all medications, GLP-1s can have side effects, which your doctor will explain. Common ones often involve the digestive system and tend to be temporary.
Preferred Administration Method: As we’ll discuss, some are injections, while one is an oral tablet. Your lifestyle and preference will be considered.

Understanding Insurance Coverage:

The cost of GLP-1 medications can be a significant consideration. Insurance coverage varies depending on your specific plan, the prescribed medication, and its approved use (diabetes vs. weight management). It’s recommended to check with your insurance provider to understand your coverage and any necessary pre-approvals. Your doctor’s office can often assist with this process.

Oral vs. Injectable GLP-1s: Delivery Options

GLP-1 medications are available in different forms:

Injectable GLP-1s: Many GLP-1s are administered via a small injection under the skin. The frequency can range from daily to weekly, depending on the specific medication. These injections are typically well-tolerated.

Oral GLP-1s: In addition to injectable GLP-1s, most weight loss medication providers offer a non-injectable option, typically a tablet or capsule, with usage guidelines that should be followed according to the instructions provided by your chosen provider.

The choice between an oral and injectable GLP-1 will depend on your preferences, lifestyle, and the specific medication recommended by your doctor.

Integrating GLP-1s into a Holistic Health Plan

Remember that GLP-1 medications are often most effective when used in combination with a healthy lifestyle. This includes a balanced and nutritious diet, regular physical activity, and ongoing support. These medications can be a valuable tool in your weight management journey, offering significant benefits when used appropriately and under medical supervision.

By gaining a clear understanding of GLP-1 medications, their mechanisms, and the factors involved in choosing and using them, you can have informed and positive discussions with your healthcare provider about whether this approach aligns with your health goals.

GLP-1 FAQs

What are GLP-1 medications?

GLP-1 medications are prescription drugs that act like a natural hormone in your body called GLP-1. This hormone helps control blood sugar and also signals to your brain that you’re full, which can reduce your appetite.

How do GLP-1 medications help with weight loss?

GLP-1 medications work by slowing down how quickly food leaves your stomach, so you feel full for longer after eating. They also reduce hunger signals in your brain, making it easier to eat less overall.

Are GLP-1 medications only for people with diabetes?

No. While they were first used for diabetes to manage blood sugar, some GLP-1 medications are now specifically approved for weight loss in people who are overweight or obese, even if they don’t have diabetes.

How quickly can I expect to see results with GLP-1 medications?

Weight loss varies from person to person, but many people start to see changes within a few weeks or months. Significant weight loss typically occurs gradually over time with consistent use and when combined with healthy eating and exercise.

Disclosures

*The assessment made available on the Remedy Meds website does not create a doctor-patient relationship between the individual completing the assessment and Remedy Meds. Remedy Meds is not a provider of medical services. Remedy Meds acts primarily as a technology platform to connect you with professional healthcare providers who may be available to provide you with non-emergency care. Such providers include JMP Medical, OpenLoop Health, and certain other medical groups (collectively, the “Providers”). The Providers include a network of US-licensed doctors that adhere to rigorous medical protocols designed for patient safety and have established exclusionary criteria to determine if an individual does not qualify for GLP-1s. Each Remedy Meds assessment will be reviewed by a Provider who will determine if the individual is eligible for GLP-1 medication and qualifies for a prescription. Provider clinicians retain the decision to prescribe compounded GLP-1s to patients.

All claims and benefits on this website refer to self-reported data from Remedy Meds customers on a treatment plan that includes compounded GLP-1 medications and consultations with medical professionals. Customers reported their weight on their initial medical intake questionnaire every 3-4 weeks thereafter. Results from compounded medications found on the Remedy Meds platform may vary and be affected by an individual’s adherence to the program and their clinician’s recommendations. Although compounded GLP-1s are produced in facilities that are highly regulated, the medications are not FDA-approved or evaluated for safety, efficacy, or quality. The decision to use compounded drugs is guided by the licensed provider’s medical judgment, which is informed by a telehealth consultation and medical history.

We encourage all prospective users of compounded medications to speak with their provider about the specific risks and benefits that may come with the use of compounded medication. Remedy Meds does not produce compounded medications, and individuals may receive medication that looks different than what is portrayed on the website.